![]() ![]() The DG-SIS scaffold containing 1 wt % of curcumin may be a potential biomaterial for wound-healing and skin tissue engineering.read more read lessĪbstract: Collagen, an abundant extracellular matrix protein, has been found to have a lot of pharmaceuticals, medicine, food, and cosmetics applications. #Caprine engineering free#However, biodegradability, free radical scavenging, biocompatibility, and antibacterial properties of the scaffolds increased with an increase in the curcumin content. The porosity and hydrophilicity of the scaffolds were decreased with an increase in the curcumin content. Besides, it showed free radicals scavenging property. Results depicted that the scaffolds are porous, biodegradable, biocompatible, antibacterial, and hydrophilic and showed sustained release of curcumin. Changes brought by increasing the concentrations of the curcumin in DG-SIS were observed in various properties, including free radical scavenging and antibacterial properties. The goat small intestine submucosa (G-SIS) is decellularized to obtain the decellularized G-SIS (DG-SIS) and curcumin (in different concentrations) was incorporated in the DG-SIS to fabricate curcumin-embedded DG-SIS scaffolds. In this study, ECM was extracted from the biowaste of the goat abattoir by using decellularization. However, oxidative stress and biofilm formation at the wound site remains a major challenge that could be neutralized using herbal ingredients (e.g., curcumin). Thus, ECM could be an ideal biomaterial for fabricating the scaffold. ECM is a complex network of biomolecules (e.g., proteins), which provide organizational support to cells for growth. Immuno-cytochemical analysis in conjugation with traction force microscopy further confirmed a superior focal adhesion complex m.read more read lessĪbstract: Biomaterials derived from extracellular matrices (ECMs) were extensively used for skin tissue engineering and wound healing. Biocompatibility study showed that GTC augmented cell adhesion, cell cycle progression and proliferation. Results revealed that GTC was comprised of type-I collagen. Physico-chemical characterization of 1% acetic acid extracted GTC was done by SDS-PAGE, amino-acid composition analysis, FT-IR and CD spectroscopy. This article delineates the isolation, physico-chemical characterization, biocompatibility study and wound healing application of acid soluble caprine (goat) tendon collagen (GTC). Keeping the aforementioned perspective in mind, we explored the possibility of using domestic goat available in the subcontinent as a potential source of collagen for tissue-engineering application. However, a risk of a spongiform encephalopathy epidemic has limited the use of collagen from these sources. ![]() ![]() Abstract: Collagens presently used in tissue engineering are primarily of bovine or porcine origin. ![]()
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